The year is 1582 and Takeshi Kaneshiro as Samanosuke is the man who has just returned. The stage is set at the burning Honnoji Temple; as the famous Onimusha warrior Samanosuke Akechi fights. As he faces the demons in front of him; Samanosuke is compelled to move forward by hatred for his true enemy; the undying Nobunaga Oda ever pursuing his crazed ambition. Samanosuke prepares for the long-awaited final battle against Nobunaga.
The year is 2004 and Jean Reno as Jacques Blanc is the man who has arrived. A peaceful French city is suddenly attacked by demons. In the blink of an eye the city is transformed into a nightmarish nest of Genma demons who are slaughtering civilians and soldiers one by one. Within this nightmare appears one man a man who stands up against the Genma demons.
Why has Samanosuke suddenly appeared in modern day Paris and Jaques in feudal Japan? What fate awaits these two men? What will be the final outcome of each